HIGHLIGHTS
- who: BMC Structural Biology and collaborators from the University of California, Berkeley, CA, USA, Department of Chemistry, California Institute for Quantitative Biosciences (QB3), Howard Hughes have published the Article: Bio Med Central, in the Journal: (JOURNAL)
- what: Using electronic absorption spectroscopy the authors show that imatinib binding results in perturbation of the protein environment around the flavin prosthetic group in NQO2. This approach has been pursued with imatinib and the second-generation inhibitors nilotinib, dasatinib, and bosutinib. The authors report studies undertaken to further understand the structural basis for the molecular mechanism by which imatinib . . .
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