Synthesis and biological activity of a cytostatic inhibitor of mllr leukemia targeting the dot1l protein

HIGHLIGHTS

  • who: Corentin Bon et al. from the Université de Paris, Sorbonne Paris Cité, Paris, France Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe , have published the research work: Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein, in the Journal: Molecules 2021, 26, 5300. of 31/08/2021
  • what: As only the substrate sugar-based analogs succeeded to go to the clinical phase, the authors focused on the modulation of these compounds. The authors report here the synthesis and biological evaluation of compound 3 Dia2 . . .

     

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