Yeast nup84-nup133 complex structure details flexibility and reveals conservation of the membrane anchoring alps motif

HIGHLIGHTS

• who: Sarah A. Nordeen from the Massachusetts Institute have published the paper: Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report the structures of the Nup84-Nup133 C-terminal α-helical domain and Nup133 N-terminal β-propeller from S. cerevisiae. The authors show that Nup133 has a functional ALPS motif through liposome interaction studies.
• how: For Nup133NTD the authors used the structure of Vanderwaltozyma polyspora Nup133NTD (PDB 4Q9T 45% sequence identity). For VHH-SAN5 the authors . . .
  

   

  

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