Nuclear envelope integrity in health and disease: consequences on genome instability and inflammation

HIGHLIGHTS

  • who: Benoit R. Gauthier and Valentine Comaills from the Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Madrid, Spain have published the research work: Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation, in the Journal: (JOURNAL)

SUMMARY

    The main role of the nuclear envelope (NE) is to compartmentalize and protect the unfolded genomic DNA from the cytoplasm in eukaryote cells. A peculiar mode of apoptosis is NETosis in which neutrophils voluntarily disrupt their nuclear envelope and plasmatic membrane in response to an infection to release DNA that . . .

     

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