Er stress-induced aggresome trafficking of htra protects against proteotoxicity

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  • who: Maximilian J. Gerhardt et al. from the Department of Ophthalmology, Harvard Medical School, The Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, MA, USA Department III of Internal Medicine, Cologne University Heart Center, Center for Molecular Medicine, University of Cologne, Cologne, Germany have published the Article: ER stress-induced aggresome trafficking of HtrA protects against proteotoxicity, in the Journal: (JOURNAL)
  • what: The authors report that HtrA1 was induced upon chronic proteotoxicity as part of the unfolded protein response (UPR). The authors demonstrate in this study that HtrA1, a multi-domain protein . . .

     

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