HIGHLIGHTS
- who: Emilie Jaune from the (UNIVERSITY) have published the research work: Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies, in the Journal: (JOURNAL)
- what: This experiment demonstrates that although CRO15 does not have exactly the same efficiency as metformin on mitochondrial respiration, it induces significant dysregulations. The authors demonstrate that CRO15 induces melanoma cell death by AMPK and p53 pathways to induce autophagy and apoptosis of melanoma cells, and this process is REDD1 dependent. with LC3 antibody, and the authors observed an increase in LC3 expression . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.