New quinoxaline derivatives as dual pim-1/2 kinase inhibitors: design, synthesis and biological evaluation

HIGHLIGHTS

• who: Bruno Oyallon and collaborators from the , CNRS, Team IMT, University of Tours, Tours, France have published the paper: New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation, in the Journal: Molecules 2021, 26, x FOR PEER REVIEW of /2021/
• what: The authors report herein the structure-activity relationships (SAR) and in vitro evaluations of acting Pim1/2 Two lead compounds (5c and 5e) were then identified potent submicromolar Pim-1 and Pim-2 These molecules were also able to inhibit the growth of the two human cell lines . . .
  

   

  

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