HIGHLIGHTS
- who: Annoj Thavalingam from the University of Suite, Toronto, ON M G , Canada have published the paper: Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors investigate the mechanism of activity of antiCRISPR protein AcrIIC2Nme. The authors show that AcrIIC2Nme functions by inhibiting loading of the guide RNA molecule, thereby preventing formation of the active CRISPR-Cas9 2 surveillance complex.
- how: As other anti-CRISPRs have been shown to have activity against multiple Cas9 orthologues23 the authors investigated the range of . . .
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