HIGHLIGHTS
- who: Juliana C. Ferreira from the (UNIVERSITY) have published the paper: Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target, in the Journal: (JOURNAL) of July/19,/2020
- what: The authors investigated the roles of the linker helix-α13 residues on the catalytic activity of the NTD of HK2 to identify a possible regulatory site.
- how: The increased kinetic thermal stabilities of the mutants could result from their inactive NTD as similar results were obtained with the D209A mutant containing an inactive NTD. The authors investigated the roles . . .
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