HIGHLIGHTS
- who: Charlotte Martinat from the Institut University of, PARIS, France have published the research work: SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that SAMHD1 undergoes SIM-mediated SUMOylation of the evolutionarily conserved K595 residue, which is part of the CDK-targeted motif driving T592 phosphorylation (592TPQK595). The authors focused the analyses on the SUMO2 paralog because (i) the pool of SUMO2 and SUMO3 available for conjugation exceeds that of SUMO144 and_(ii) SUMO2 and SUMO3 . . .
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