The rational development of cd5-targeting biepitopic cars with fully human heavy-chain-only antigen recognition domains

HIGHLIGHTS

• who: Zhenyu Dai from the Tongji Hospital Huazhong University Biotherapeutics, Nanjing, Jiangsu, China have published the article: The rational development of CD5-targeting biepitopic CARs with fully human heavy-chain-only antigen recognition domains, in the Journal: (JOURNAL)
• what: The authors report the selection of novel CD5-targeting fully human heavy-chain variable (FHVH) domains for the development of a biepitopic CAR termed FHVH3/VH1 containing FHVH1 and FHVH3 which were validated to bind different epitopes of the CD5 antigen.
• how: The results showed that FHVH3/VH1 CAR-T_cells cleared T-ALL cells . . .
  

   

  

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