HIGHLIGHTS
- who: Ashwin Narain from the ΓΌ rzburg, Germany University of have published the article: Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination, in the Journal: (JOURNAL)
- what: From these observations, the authors propose that SPT6 has a dual effect on RNAPII transcription : On one hand, SPT6 primarily promotes RNAPII elongation.
- how: Experiments were analyzed in this time frame. SPT6 is essential for RNAPII termination and prevents readthrough transcription Metagene analysis of 4sU-seq data indicated that acute SPT6 depletion resulted not only in a strong elongation defect but . . .
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