Propagation of α-synuclein strains within human reconstructed neuronal network

HIGHLIGHTS

  • who: Simona Gribaudo from the , STEM, AFM, Corbeil-Essonnes, France have published the paper: Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network, in the Journal: (JOURNAL) of February/12,/2019
  • what: The authors provide unique experimental evidence that different strains of human a-Syn disseminate in "wild-type" human neuronal networks in a prion-like manner. The authors show that two distinct a-Syn strains the authors named fibrils and ribbons are transported traffic between neurons and trigger to different extents in a dose- and structure-dependent manner the progressive accumulation of PD-like . . .

     

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