Nuclear exosome targeting complex core factor zcchc8 regulates the degradation of line1 rna in early embryos and embryonic stem cells

HIGHLIGHTS

  • who: You Wu from the East Hospital Tongji University, Shanghai, China have published the research: Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells, in the Journal: (JOURNAL) of November/19,/2019
  • how: RNA sequencing (RNA-seq) data showed that Zcchc8 mRNA was highly expressed in MII oocytes and zygotes and relatively downregulated after the two-cell stage (Liu et_al 2016 Figure S1A). This result is consistent with the previous studies of observed increased RNA level of NEXT complex targeted eRNAs and PROMPTs in . . .

     

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