Loss of atm accelerates pancreatic cancer formation and epithelial–mesenchymal transition

HIGHLIGHTS

  • who: Ronan Russell from the Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee, Ulm, Germany, Institute of Neuroanatomy, Eberhard Karls University have published the article: Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 29/07/2015
  • what: The authors report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. Particularly the authors report that low expression of ATM predicts EMT a gene signature specific for Bmp4 . . .

     

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