Dna damage-induced histone h1 ubiquitylation is mediated by huwe1 and stimulates the rnf8-rnf168 pathway

HIGHLIGHTS

• who: I. K. Mandemaker from the (UNIVERSITY) have published the Article: DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway, in the Journal: (JOURNAL) of 27/04/2017
• what: Based on the data the authors propose a model in which HUWE1 is important for the initial damage-induced ubiquitylation of histone H1.
• how: The authors identified several peptides from proteins that were previously described to be ubiquitylated in response to DNA damage including XPC1924 DDB234 and FANCD235 (Supplemental Fig S1c) providing the proof of principle of . . .
  

   

  

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