Rapid transcriptional pulsing dynamics of high expressing retroviral transgenes in embryonic stem cells

HIGHLIGHTS

  • who: Mandy Y. M. Lo and collaborators from the Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada, INRA have published the research: Rapid Transcriptional Pulsing Dynamics of High Expressing Retroviral Transgenes in Embryonic Stem Cells, in the Journal: (JOURNAL) of May/14,/2012
  • what: The authors used the MS2 system to demonstrate that discontinuous transcription occurs from highly expressed retroviral transgenes in ES cells. The authors propose that high expression levels in any given cell clone ultimately are a consequence of the overall . . .

     

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