Tdp-43 regulation of ache expression can mediate als-like phenotype in zebrafish

HIGHLIGHTS

• who: Maria-Letizia Campanari and collaborators from the Institut National de la Santé et de la Recherche Médicale (INSERM) Unité, Centre National de la Recherche have published the research: TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish, in the Journal: Cells 2021, 10, 221. of /2021/
• how: The authors identified AChE as a limiting factor regulating muscle/motor neuron connection in a vertebrate model of ALS. The authors employed the zf model previously described by the team where knockdown of tdp-43 leads to symptoms reminiscent of ALS disease . . .
  

   

  

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