Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose warburg effect

HIGHLIGHTS

  • who: Qiang Zhang from the (UNIVERSITY) have published the research: Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect, in the Journal: (JOURNAL)
  • what: The authors explored whether TP upregulation affects the metabolic reprogramming of HCC and whether the transcriptional pattern of Twist1-TP could contribute to VM formation in HCC.
  • how: Kaplan-Meier survival analysis results showed that the high TP expression significantly affected the survival prognosis of patients with HCC with clinical parameters of stage ≥II metastasis or CEA content >3.4 ng/mL AFP content >400 ng . . .

     

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