Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase c-dependent regulation*

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• who: James D. Foster from the James DFoster and Roxanne A. Vaughan, From the Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, Palmitoylation is a lipid modification that confers diverse functions to target proteins and is a contributing factor for many neuronal diseases. In this study, we demonstrate using [ H]palmitic acid labeling and acyl-biotinyl exchange that native and expressed dopamine transporters (DATs) are palmitoylated, and using the palmitoyl acyltransferase inhibitor, bromopalmitate ( BP), we identify several associated functions. Treatment of rat striatal synaptosomes with . . .
  

   

  

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