Carm1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells

HIGHLIGHTS

• who: Min Nie from the (UNIVERSITY) have published the Article: CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells, in the Journal: (JOURNAL) of May/22,/2018
• what: The authors show that CARM1-mediated methylation of PRMT5 is essential for the intracellular homodimerization of PRMT5 to its active form. The authors demonstrated that PRMT5 was methylated at arginine 505 and that this modification affected the methyltransferase activity of PRMT5. The study shows that the methylation of PRMT5 Arg-505 had no effect on the association of PRMT5 with . . .
  

   

  

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