The role of multicellular aggregation in the survival of erbb2-positive breast cancer cells during extracellular matrix detachment*

HIGHLIGHTS

• who: Raju R. Rayavarapu from the Raju RRayavarapu, Brendan Heiden1, Nicholas Pagani1, Melissa M. Shaw, Sydney Shuff, Siyuan Zhang2, and Zachary T. Schafer, From the Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana , Background: Cancer cells evade death caused by extracellular matrix (ECM)-detachment to facilitate metastasis. Results: ErbB2-expressing cancer cells form aggregates during ECM-detachment that promote survival signaling through EGFR. Conclusions: Multicellular aggregation in Erb, positive cancer cells promotes survival by preventing EGFR degradation. Significance: Disrupting aggregation or inhibiting EGFR may be effective strategies to eliminate ErbB2-expressing cancer cells during . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.