3584-3599 general article general article neuronal over-expression of oxr1 is protective against als-associated mutant tdp-43 mislocalisation in

HIGHLIGHTS

• who: Matthew G. Williamson and collaborators from the of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford , PT, UK have published the article: 3584-3599 General Article GENERAL Article Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in, in the Journal: (JOURNAL) of July/26,/2019
• what: The authors show in primary motor neurons from TDP-43M337V mice that genetically-driven Oxr1 over-expression significantly alleviates cytoplasmic mislocalization of mutant TDP-43. Given that Oxr1 over-expression can delay pathogenesis in the hSOD1G93A model and reduce mislocalization . . .
  

   

  

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