HIGHLIGHTS
- who: Maria Katsarou from the Institut"Demokritos, " Agia Paraskevi, Athens, Greece have published the paper: Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy, in the Journal: (JOURNAL)
- what: The analysis showed that, upon incubation at 37°C for 24 h, the three apoE3 mutants R25C, R114C, and A152D displayed a significant shift to larger hydrodynamic diameters as compared with their hydrodynamic diameter before incubation, in contrast to the WT apoE3, which was stable (Fig 8A-D).
SUMMARY
Human apoE has three common . . .
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