HIGHLIGHTS
- who: Enhanced Sampling Methods and colleagues from the Italy Italy Italy have published the article: Substrate Binding Process and Mechanistic Functioning of Type 1 11 b -Hydroxysteroid Dehydrogenase from Enhanced Sampling Methods, in the Journal: (JOURNAL) of September/23,/2011
- what: The work highlights a) the reason behind the functional dimerisation of 11b-HSD-1 b) the key role of Y177 in the cortisone binding event c) the fine tuning of the active site degree of solvation and d) the role of the S228-P237 loop in ligand recognition. The aim of the SMD simulations . . .
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