Anesthetics and cell-cell communication: potential ca2+-calmodulin role in gap junction channel gating by heptanol, halothane and isoflurane

HIGHLIGHTS

  • who: Camillo Peracchia from the Department of Pharmacology and Physiology, School of Medicine and Dentistry, University Rochester have published the article: Anesthetics and Cell-Cell Communication: Potential Ca2+-Calmodulin Role in Gap Junction Channel Gating by Heptanol, Halothane and Isoflurane, in the Journal: (JOURNAL)
  • what: As a result, the authors propose an alternative hypothesis, that cell-cell uncoupling by anesthetics may result from CaM's activation caused by anestheticinduced i rise, and increased Ca2+ sensitivity in CaM. In view of these findings, while the authors cannot exclude a direct effect of anesthetics on gap junction . . .

     

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