Tripartite assembly of rnd multidrug efflux pumps

HIGHLIGHTS

  • who: Laetitia Daury from the France, Institute of Biochemistry, Goethe-University Frankfurt, Max-von-Laue-Str., Frankfurt am Main, Germany. have published the research work: Tripartite assembly of RND multidrug efflux pumps, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 12/02/2016
  • what: The authors report the reconstitution of native MexAB-OprM, AcrAB-TolC and interspecies AcrA-MexB-TolC complexes using nanodisc (ND) technology39. The authors provide evidence for a common mechanism of tripartite assembly with cognate and non-cognate components, whereby MFP molecules link their cognate OMF partners to cognate and non-cognate . . .

     

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