HIGHLIGHTS
- who: POSTER PRESENTATION and collaborators from the (UNIVERSITY) have published the article: Leaky Ryanodine receptors increases Amyloid- beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease, in the Journal: (JOURNAL)
- what: The authors investigate whether APP perturbs ER Ca2+ homeostasis and whether ER Ca2+ could in turn influence amyloid beta production. The authors show that overexpression of APP695, or APPs the authors triggers increased Ryanodine receptors (RyR) expression and enhances RyR-mediated ER Ca2+ release in SH-SY5Y neuroblastoma cells and in APPswe-expressing (Tg2576) mice.
SUMMARY
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