Regulation of g protein-coupled receptors by

HIGHLIGHTS

• who: Goddard and collaborators from the (UNIVERSITY) have published the research work: Regulation of G protein-coupled receptors by, in the Journal: (JOURNAL)

SUMMARY

Directed to elucidating GPCR crystal_structures and a number of the structures obtained seem to indicate the presence of receptor dimers. Intriguingly, the β2-adrenergic receptor (β2AR) crystalized with cholesterol molecules and a post-translationally added palmitate group from each protomer forming most of the dimer interface, suggesting a role for lipids and sterols, in addition to protein-protein interactions, in GPCR dimeri­zation. Preventing palmitoylation reduced the association of . . .

 



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