HIGHLIGHTS
- who: Paul J. Meakin and colleagues from the DivisionUniversity of, Dundee, United Kingdom have published the article: Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction, in the Journal: (JOURNAL)
- what: The authors report that diet-induced obesity (DIO) in mice increased plasma and vascular Aβ42 that correlated with decreased NO bioavailability endothelial dysfunction and increased blood pressure. The authors demonstrate that chronic HF feeding of mice, causing obesity and hyperglycemia, raises BACE1 activity as monitored by changes in sAPPβ levels, although the levels of this peptide may also be affected by . . .
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