Antibiotic-induced cell chaining triggers pneumococcal competence by reshaping quorum sensing to autocrine-like signaling

HIGHLIGHTS

• who: Arnau Domenech from the Faculty University of Switzerland have published the article: Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like Signaling, in the Journal: (JOURNAL) of November/27,/2018
• what: The authors demonstrate that aztreonam (ATM) and clavulanic acid (CLA) promote The authors show that both compounds induce cell chain formation by targeting the D D-carboxypeptidase PBP3. support of the hypothesis that chain formation promotes the authors demonstrate that an autolysin mutant (DlytB) is hypercompetent. Both ATM and CLA target the non-essential PBP3 of S. pneumoniae . . .
  

   

  

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