Fine-tuning of optimal tcr signaling in tumor-redirected cd8 t cells by distinct tcr affinity-mediated mechanisms

HIGHLIGHTS

• who: Michaël Hebeisen from the Department of Oncology, Lausanne Hospital Center, of Lausanne, Lausanne, Switzerland, Protein have published the article: Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms, in the Journal: (JOURNAL)
• what: The authors aimed at spatially and temporally dissect the impact of TCR-pMHC affinity on the signal intensity, amplification-gain and duration of the proximal (i.e., CD3ζ and LCK) and distal (i.e., ERK1/2) TCR signaling nodes. Together, the authors propose that adjusted TCR-peptide/self-MHC interactions might . . .
  

   

  

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