Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy

HIGHLIGHTS

  • who: Liwei Gu from the (UNIVERSITY) have published the paper: Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy, in the Journal: (JOURNAL) of 24/03/2022
  • what: The authors provide the first evidence that the anti-tumor effect of TPP-SS-ATS-LS is the regulation of PINK1 dependent mitophagy probably connected with downregulating the expression of PHB2.
  • how: In this paper technical methods such as transmission electron microscopy (TEM) differential scanning calorimetry (DSC) and molecular dynamics simulation were used to systematically evaluate the nanopharmaceutical characteristics of TPP-SS-ATS . . .

     

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