Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters slc16a2 (mct8) and slc16a10 (mct10)

HIGHLIGHTS

• who: David S. Sharlin from the Mouse StrainsThe null allele of Slc16a, (Mct8) was previously reported52. The Slc16a, (Mct10) null allele carries a premature stop at codon , (Y88*), which truncates most of the protein including , of , transmembrane domains35. Double mutant (dko) mice were originally on a C BL/, (Charles River) background, and at NIH were further backcrossed for up to , generation onto a C BL6/J (Jackson Lab) background. Slc16a2deficient groups were generated by crossing Slc16a2+/- females with y/- males. Slc16a10-deficient groups were generated by crossing Slc16a10+/- males and females. Groups of dko mice were generated . . .
  

   

  

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