HIGHLIGHTS
- who: Emilie Giraud from the Institut have published the paper: Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication, in the Journal: Scientific Reports Scientific Reports of 25/01/2021
- what: As NS5 of Flaviviruses provides RNA cap MTase and RdRp activities, the authors focused the efforts to determine whether the PBM of WNV NS5 affects virus replication. The authors showed that the PBM (-TVLCOOH) motif at the C-terminus of WNV NS5 protein interacts with human PDZ domains in_vitro but is also capable of interacting with cellular PDZ-containing . . .
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