HIGHLIGHTS
- who: Romain Mustière et al. from the (UNIVERSITY) have published the research: molbank, in the Journal: (JOURNAL)
SUMMARY
Initially discovered in South-East Asia, where they have become widespread, kelch13 mutations are now found in Africa, where they have recently been linked to in_vitro resistances against artemisinin derivatives. This led to the idea of replacing the pyrimidinone moiety by a diazaborinin-4-one moiety, seeking to synthesize compounds in thien [1,3,2]diazaborinin-4-one series and assess their activity in_vitro against multi-resistant P. falciparum K1 strain (Scheme 1). This . . .
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