Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

HIGHLIGHTS

  • who: W Mark Erwin and colleagues from the Abbreviations ADAMTS: a disintegrin and metalloproteinase with thrombospondin motifs have published the research: Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration, in the Journal: (JOURNAL) of 29/Dec/2011
  • what: The authors assessed the apoptotic pathway(s) involved in the IL-1b and FasL induced apoptosis of bovine NP cells under hypoxic conditions. For the first time the authors demonstrate that soluble factors secreted by notochordal cells (notochordal cell conditioned medium or ‘NCCM') are capable of protecting . . .

     

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