Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for fhm2

HIGHLIGHTS

• who: Lieke Kros from the (UNIVERSITY) have published the paper: Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2, in the Journal: (JOURNAL) of 19/07/2018
• what: The authors show that a mouse model for FHM2 harboring the G301R mutation shows an increased susceptibility to both CSD and generalized epileptiform activity in awake animals.
• future: Future pre-clinical studies should be carried out to investigate this phenomenon further for example by examining whether pharmacological or surgical ablation of sex hormones would also decrease susceptibility to CSD . . .
  

   

  

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