HIGHLIGHTS
- who: Mohammad A. Makrooni from the (UNIVERSITY) have published the research work: Bias and inconsistency in the estimation of tumour mutation burden, in the Journal: (JOURNAL)
- what: The authors show that because only mutations with an observed frequency greater than the threshold are considered the observed mutant allele frequency provides a biased estimate of the true frequency. The authors investigate statistical biases affecting TMB estimation. The authors explore the impact of these biases on TMB estimates using simulations with parameters informed by real cancer sequencing studies. Theoretical derivation of the relative error in the TMB . . .
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