Egf promotes pkm2 o-glcnacylation by stimulating o-glcnac transferase phosphorylation at y976 and their subsequent association

HIGHLIGHTS

• who: Yang Wang from the Normal University, Renmin Street, Changchun, Jilin, China have published the article: EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association, in the Journal: (JOURNAL)
• what: The authors showed that EGF stimulated the phosphorylation of OGT at Y976 and in turn promoted OGT binding to PKM2.
• how: These results showed that EGF-induced upregulation in PKM2 O-GlcNAcylation and detetramerization reduced the enzymatic activity of PKM2. Data were analyzed using Prism Version 8 software (GraphPad).
• future: How PTMs on . . .
  

   

  

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