HIGHLIGHTS
- who: Julien Dugal-Tessier and colleagues from the (UNIVERSITY) have published the Article: Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates, in the Journal: (JOURNAL)
- what: This approach has allowed an improvement of the therapeutic index of many antibodies. This work shows how cause it helped the oligonucleotide escape the endosomes. Two examples of this approach have been documented, and both have used trastuzumab as the targeting antibody . This approach has been modified where the AOC is a carrier for a cytotoxin like an A ADC .
- how: This was used generatetoAOCs foronly . . .
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