Hash1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon re

HIGHLIGHTS

• who: Jennifer A. Fraser from the SchoolNapier University have published the paper: hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon re, in the Journal: Scientific Reports Scientific Reports
• what: The authors show, for the first time, that intermittent androgen deprivation and loss of AR signalling may promote the existence of "hybrid" prostate cancer cells that retain both NE-like and epithelial qualities, most notably persistent nuclear localisation of hASH1.
• future: Future work will establish if ASCL1 expression is directly regulated by AR signalling. hASH1 localisation appears to be sensitive . . .
  

   

  

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