Enhanced opioid efficacy in opioid dependence is caused by an altered signal transduction pathway

HIGHLIGHTS

• who: Altered Signal Transduction Pathway et al. from the DepartmentThe University New South Wales, Australia have published the research: Enhanced Opioid Efficacy in Opioid Dependence Is Caused by an Altered Signal Transduction Pathway, in the Journal: (JOURNAL) of December/15,/1998

SUMMARY

Tolerance, or a diminished responsiveness to the inhibitory actions of opioids, has been widely demonstrated to occur in opioid-sensitive cells and is thought to involve f unctional uncoupling between opioid receptors and their effectors (Law et_al, 1982; Chavkin and Goldstein, 1984; Christie et_al, 1987; Puttfarcken et_al, 1988). Clear evidence of . . .

 



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