HIGHLIGHTS
- who: Liora S. Katz from the (UNIVERSITY) have published the paper: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure, in the Journal: (JOURNAL) of 16/Dec/2021
- what: The authors show that the hyperactive isoform of carbohydrate response-element binding protein (ChREBPβ) is a nuclear effector of hyperglycemic stress occurring in β-cells in response to prolonged glucose exposure, high-fat diet, and diabetes. The authors show that transient positive feedback induction of ChREBPβ is necessary for adaptive β-cell expansion in response to metabolic challenges.
- future: Clearly more studies are needed to . . .
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