Activation of polyamine catabolism by n1 n11-diethylnorspermine in hepatic induces dedifferentiation

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  • who: HepaRG and colleagues from the Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaCancer Research Center Lyon, INSERM , and CNRS, Lyon University, Lyon, France have published the research work: Activation of Polyamine Catabolism by N1 N11-Diethylnorspermine in Hepatic Induces Dedifferentiation, in the Journal: Cells 2018, 275 of /2018/
  • what: The aim of the study was to explore whether interference with the metabolism of biogenic polyamines can induce EMT using the immortalized non-transformed liver cell line HepaRG. The authors show that DENSpm-augments catabolism of spermine and spermidine and induces an . . .

     

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