Peptide centric vβ specific germline contacts shape a specialist t cell response

HIGHLIGHTS

• who: Yang Wang from the National Institute for Viral Disease China University of Hamburg, Germany have published the research work: Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response, in the Journal: (JOURNAL) of April/26,/2019
• what: The authors show that the Ld-HF10-specific T_cell response displays a focused TCR repertoire dominated by Vb2.
• how: For in_vitro T_cell activation assays the authors used mice expressing a rearranged TCR transgene derived from a CD8 T_cell clone specific for the HF10 peptide (HPGSVNEFDF corresponding to the C-terminus of the . . .
  

   

  

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