Wnt4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro

HIGHLIGHTS

• who: Xiaonan Zhang from the Universitéde Versailles SaintQuentin-en-Yvelines, France Tokushima University, Japan have published the research: WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro, in the Journal: (JOURNAL)
• what: Since the authors report that neoplastic pTECs in 3D culture maintain the WNT4+FOXN1+ phenotype of TETs much longer than in 2D cultures, the authors hypothesize that tumor cell- tumor cell and tumor cell-matrix interactions may be important to maintain the autocrine WNT4 loop, FOXN1 expression, and tumor cell survival of TETs in_vivo . . .
  

   

  

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