Interdiction in the early folding of the p53 dna-binding domain leads to its amyloid-like misfolding

HIGHLIGHTS

• who: Fernando Bergasa-Caceres and Herschel A. Rabitz from the (UNIVERSITY) have published the research work: Interdiction in the Early Folding of the p53 DNA-Binding Domain Leads to Its Amyloid-like Misfolding, in the Journal: Molecules 2022, 27, x FOR PEER REVIEW of /2022/
• what: The authors investigate two issues: (a) the initial contact formation events along the folding pathway of the DNA-binding domain of the tumor suppressor protein p53 (core p53); and_(b) the intermolecular events leading to its conversion into a prion-like form upon incubation with peptide P8(250-257 . . .
  

   

  

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