HIGHLIGHTS
- who: Emiko Kranz from the The Rockefeller University, United States have published the article: Efficient derivation of chimeric-antigen receptor-modified TSCM cells, in the Journal: (JOURNAL)
- how: In an assay for anti-CD19 CAR (FMC63-IgG4z ) the authors used BCBL-1 (CD19- non-target cells) and Ramos cells (CD19+ target cells).
SUMMARY
Gene-engineered T_cells with desired antigen-specific receptors such as chimeric-antigen receptors (CARs), aim to confer directed and enhanced cytotoxic T lymphocyte responses. When a CAR encounters its target ligand, it signals the cell in a T_cell . . .
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