HIGHLIGHTS
- who: Christophe Pellefigues from the CNRS Dental University have published the paper: Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: As the production of potent basophil activators or chemoattractants is dysregulated during lupus pathogenesis28, here the authors explore the mechanisms underlying basophil recruitment to SLO during SLE. The authors show that disease activity and basopenia, which are tightly linked together, are related to PGD2/PTGDR and CXCL12/CXCR4 axes. The authors demonstrate that basophils from SLE patients and lupus-prone mice were able to . . .
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